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consists of Chlorzoxazone, Ibuprofen.

Chlorzoxazone (Profenazone)

What is Chlorzoxazone (Profenazone)

Chlorzoxazone (Profenazone) is a muscle relaxer. It works by blocking nerve impulses (or pain sensations) that are sent to your brain.
Chlorzoxazone (Profenazone) is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.
Chlorzoxazone (Profenazone) may also be used for purposes not listed in Chlorzoxazone (Profenazone) guide.

Chlorzoxazone (Profenazone) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using Chlorzoxazone (Profenazone) and call your doctor at once if you have any of these serious side effects:

Less serious side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)

Chlorzoxazone (Profenazone) dosing

Usual Adult Dose for Muscle Spasm:

250 to 750 mg orally 3 to 4 times a day.
The dosage may be reduced as the condition of the patient improves.

Usual Pediatric Dose for Muscle Spasm:

125 to 500 mg orally 3 to 4 times a day.
Alternative dosing: 20 mg/kg/day in divided doses 3 to 4 times a day.

Ibuprofen (Profenazone)

What is Ibuprofen (Profenazone)

Ibuprofen (Profenazone) is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen (Profenazone) works by reducing hormones that cause inflammation and pain in the body.
Ibuprofen (Profenazone) is used to reduce fever and treat pain or inflammation caused by many conditions such as headache, toothache, Ibuprofen (Profenazone), arthritis, menstrual cramps, or minor injury.
Ibuprofen (Profenazone) may also be used for purposes not listed in Ibuprofen (Profenazone) guide.

Ibuprofen (Profenazone) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking Ibuprofen (Profenazone) and seek medical attention or call your doctor at once if you have any of these serious side effects:

Less serious side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)

Ibuprofen (Profenazone) dosing

Usual Adult Dose for Dysmenorrhea:

200 to 400 mg orally every 4 to 6 hours as needed.

Usual Adult Dose for Osteoarthritis:

Initial dose: 400 to 800 mg orally every 6 to 8 hours.
Maintenance dose: May be increased to a maximum daily dose of 3200 mg based on patient response and tolerance.

Usual Adult Dose for Rheumatoid Arthritis:

Initial dose: 400 to 800 mg orally every 6 to 8 hours.
Maintenance dose: May be increased to a maximum daily dose of 3200 mg based on patient response and tolerance.

Usual Adult Dose for Headache:

Study - Prevention of Electroconvulsive therapy (ECT)-induced headache:
600 mg orally 90 minutes prior to the initial ECT session

Usual Adult Dose for Pain:

Oral: Mild to moderate pain:
200 to 400 mg orally every 4 to 6 hours as needed. Doses greater than 400 mg have not been proven to provide greater efficacy.
IV: (Patients should be well hydrated before IV Ibuprofen (Profenazone) administration):
Pain: 400 to 800 mg intravenously over 30 minutes every 6 hours as needed.

Usual Adult Dose for Fever:

Oral:
200 to 400 mg orally every 4 to 6 hours as needed.
IV: administration):
Fever: Initial: 400 mg intravenously over 30 minutes
Maintenance: 400 mg every 4 to 6 hours or 100 to 200 mg every 4 hours as needed.

Usual Pediatric Dose for Fever:

Greater than 6 months to 12 years:
5 mg/kg/dose for temperature less than 102.5 degrees F (39.2 degrees C) orally every 6 to 8 hours as needed.
10 mg/kg/dose for temperature greater than or equal to 102.5 degrees F (39.2 degrees C) orally every 6 to 8 hours as needed.
The recommended maximum daily dose is 40 mg/kg.
OTC pediatric labeling (analgesic, antipyretic): 6 months to 11 years: 7.5 mg/kg/dose every 6 to 8 hours; Maximum daily dose: 30 mg/kg

Usual Pediatric Dose for Pain:

Infants and Children: 4 to 10 mg/kg orally every 6 to 8 hours as needed.
The recommended maximum daily dose is 40 mg/kg.
OTC pediatric labeling : 6 months to 11 years: 7.5 mg/kg/dose every 6 to 8 hours; Maximum daily dose: 30 mg/kg

Usual Pediatric Dose for Rheumatoid Arthritis:

6 months to 12 years:
Usual: 30 to 40 mg/kg/day in 3 to 4 divided doses; start at lower end of dosing range and titrate; patients with milder disease may be treated with 20 mg/kg/day; doses greater than 40 mg/kg/day may increase risk of serious adverse effects; doses greater than 50 mg/kg/day have not been studied and are not recommended.
Maximum dose: 2.4 g/day

Usual Pediatric Dose for Cystic Fibrosis:

Oral: Chronic twice daily dosing adjusted to maintain serum concentration of 50 to 100 mcg/mL has been associated with slowing of disease progression in pediatric patients with mild lung disease.

Usual Pediatric Dose for Patent Ductus Arteriosus:

Ibuprofen (Profenazone) lysine:
Gestational age 32 weeks or less, birth weight: 500 to 1500 g:
Initial dose: 10 mg/kg, followed by two doses of 5 mg/kg after 24 and 48 hours
Note: Use birth weight to calculate all doses. Hold second or third doses if urinary output is less than 0.6 mL/kg/hour; may give when laboratory studies indicate renal function is back to normal. A second course of treatment, alternative pharmacologic therapy, or surgery may be needed if the ductus arteriosus fails to close or reopens following the initial course of therapy.


Select the most affordable brand or generic drug


StrengthQuantityPrice, USDCountry
200 mg10 $0.04
200 mg x 10's $0.05
Myofen 200mg TAB / 10 $0.05
MYOFEN tab 200 mg x 10's $0.05Nulife
400 mg x 10's $0.08
Myofen 400mg TAB / 10 $0.08
MYOFEN tab 400 mg x 10's $0.08Nulife
Paraflax Tablet $0.04Johnson & Johnson Ltd
PARAFLAX 400MG/250MG TABLET 1 strip(s) (10 tablets each) $0.38Johnson & Johnson Ltd
10 's $0.66
Paraflax Chlorzoxazone 250 mg, ibuprofen 200 mg. TAB / 10 $0.66
Paraflax Chlorzoxazone 250mg, Ibuprofen200mg TAB / 10 $0.66
PARAFLAX tab 10's $0.66J & J (Ethnor)

References

  1. Dailymed."Ibuprofen: dailymed provides trustworthy information about marketed drugs in the united states. dailymed is the official provider of fda label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."Chlorzoxazone: dailymed provides trustworthy information about marketed drugs in the united states. dailymed is the official provider of fda label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. "Ibuprofen". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Profenazone - Frequently asked Questions

Can Profenazone be stopped immediately or do I have to stop the consumption gradually to ween off?

In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.

It's wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.

What other drugs will affect Ibuprofen (Profenazone)?

Ask your doctor before using an antidepressant such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft). Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.

Tell your doctor about all other medicines you use, especially:

This list is not complete and other drugs may interact with Ibuprofen (Profenazone). Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

How should I take Chlorzoxazone (Profenazone)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take the medicine with a full glass of water.

Chlorzoxazone (Profenazone) is only part of a complete program of treatment that may also include rest, physical therapy, or other pain relief measures. Follow your doctor's instructions.

Store Chlorzoxazone (Profenazone) at room temperature away from moisture and heat.

How should I take Ibuprofen (Profenazone)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Do not take more of this medication than is recommended. An overdose of Ibuprofen (Profenazone) can cause damage to your stomach or intestines. The maximum amount of Ibuprofen (Profenazone) for adults is 800 milligrams per dose or 3200 mg per day (4 maximum doses). Use only the smallest amount of Ibuprofen (Profenazone) needed to get relief from your pain, swelling, or fever.

Take Ibuprofen (Profenazone) with food or milk to lessen stomach upset.

Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

The Ibuprofen (Profenazone) chewable tablet must be chewed before you swallow it.

If you take Ibuprofen (Profenazone) for a long period of time, your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects. Do not miss any scheduled visits to your doctor.

Store at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.

Who should not take Chlorzoxazone (Profenazone)?

You should not use this medication if you are allergic to Chlorzoxazone (Profenazone).

To make sure you can safely take Chlorzoxazone (Profenazone), tell your doctor if you have liver disease.

This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether Chlorzoxazone (Profenazone) passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Who should not take Ibuprofen (Profenazone)?

Do not use Ibuprofen (Profenazone) just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

This medicine may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term.

This medicine may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking Ibuprofen (Profenazone), especially in older adults.

You should not use this medication if you are allergic to Ibuprofen (Profenazone), aspirin or other NSAIDs.

Ask a doctor or pharmacist if it is safe for you to take this medication if you have:

FDA pregnancy category D. Taking Ibuprofen (Profenazone) during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using Ibuprofen (Profenazone).

It is not known whether Ibuprofen (Profenazone) passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not give this medicine to a child without the advice of a doctor.

What other drugs will affect Chlorzoxazone (Profenazone)?

Before using Chlorzoxazone (Profenazone), tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by Chlorzoxazone (Profenazone).

This list is not complete and other drugs may interact with Chlorzoxazone (Profenazone). Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Can Profenazone be taken or consumed while pregnant?

Please visit your doctor for a recommendation as such case requires special attention.

Can Profenazone be taken for nursing mothers or during breastfeeding?

Kindly explain your state and condition to your doctor and seek medical advice from an expert.

Reviews

Following the study conducted by gmedication.com on Profenazone, the result is highlighted below. However, it must be clearly stated that the survey and result is based solely on the perception and impression of visitors and users of the website as well as consumers of Profenazone. We, therefore, urge readers not to base their medical judgment strictly on the result of this study but on test/diagnosis duly conducted by a certified medical practitioners or physician.

Patient reports

Patient reported useful

No survey data has been collected yet


Patient reported side effects

No survey data has been collected yet


Patient reported price estimates

No survey data has been collected yet


Patient reported frequency of use

No survey data has been collected yet


One patient reported doses

What is the specific doses you have used?
Profenazone May come in various doses. In most cases, antibiotics, antihypertensive, pain killers and anti-diabetic drugs available in different doses. Your doctor may prescribe any of the doses based on the severity of the patient's condition. According to our reports, users of gmedication.com used the drugs in the following dosage percentage (Provide dosage percentage). Only a handful of drugs are made in a single or fixed dose. Regular health conditions like fever have similar doses. For instance [acetaminophen, 500mg] was used by the patients surveyed although it comes in different doses.
Patients%
51-100mg1
100.0%


One patient reported time for results

How long will I use Profenazone before I begin to notice the effect?
According to the report by users of gmedication.com, about 1 day and a few days was the most common time duration among the participants, before they began to feel relief in their health conditions. It is noteworthy that you may not get the same result with other users within the same time frame. Several factors determine the timeframe; hence we implore you to consult your medical expert to get professional advice on how long you should expect to see improvement while consuming Profenazone. However, if you wish to get the response of other users on the time effectiveness of using Profenazone kindly click here
Patients%
1 day1
100.0%


Patient reported administration

No survey data has been collected yet


One patient reported age

Patients%
16-291
100.0%


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The information was verified by Dr. Vishal Pawar, MD Pharmacology